Aprecap 125/80

Aprepitant, sold under the brand name Emend among others, is a medication used to prevent chemotherapy-induced nausea and vomiting and to prevent postoperative nausea and vomiting. It may be used together with ondansetron and dexamethasone. It is taken by mouth or administered by intravenous injection. A prodrug, fosaprepitant, is also available for intravenous administration.

Aprepitant is a selective antagonist of the neurokinin 1 (NK1) receptor, a medication primarily used to prevent acute and delayed nausea and vomiting induced by highly or moderately emetogenic chemotherapy.[1] It functions by blocking the action of substance P, a neuropeptide involved in the emetic reflex, in the central nervous system and gastrointestinal tract, thereby inhibiting emesis signals.[2] Chemically, aprepitant is a white to off-white crystalline solid with the molecular formula C23H21F7N4O3 and a molecular weight of 534.43, making it practically insoluble in water but sparingly soluble in ethanol and isopropyl acetate.[3]